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Estimating mortality in women with triple-negative breast cancer: The 'ESTIMATE triple-negative' tool.
- Source :
-
European Journal of Cancer . Aug2023, Vol. 189, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
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Abstract
- Triple-negative breast cancer (TNBC) is associated with a high risk of breast cancer-specific mortality (BCSM). Estimating the risk of BCSM and non-BCSM in TNBC would aid clinical decision-making. We developed the tool 'ESTIMATE-TN', to assess BCSM, non-BCSM, and all-cause mortality in non-metastatic TNBC. Using Surveillance, Epidemiology, and End Results (SEER), we created an interactive tool that provides a nonparametric estimate of the cumulative risk of BCSM and non-BCSM between years 0 and 7 from diagnosis, accounting for baseline clinical and pathologic variables, using Gray's subdistribution method. We included 37,293 women with TNBC diagnosed during 2010–2017. Most patients were White (71.9%) and aged 50–69 years (51.3%). Most tumour characteristics were high-grade (78.6%), T2 (42.4%), and N0 (69.5%). ESTIMATE-TN allows to input patient and tumour characteristics, and the preferred timeframe. For example, patients aged 50–59 years with a new diagnosis of T2, N1, high-grade TNBC have a risk of BCSM at 7 years of 30.8% (95% confidence interval [CI]: 26.3–35.4%) and a risk of non-BCSM over the same period of 2.8% (95% CI: 1.3–4.3%). After 3 years from initial diagnosis, the residual cumulative risks of BCSM and non-BCSM at 7 years are 17.4% (95% CI: 12.6–22.2%) and 1.1% (95% CI: 0–2.5%), respectively. ESTIMATE-TN is an interactive tool for TNBC that can be used to integrate population-based risks of BCSM and non-BCSM based on patient and tumour characteristics, facilitating our understanding of competing risks of death, which can aid clinical decision-making. • TNBC is associated with a high risk of BCSM. • We developed a tool, 'ESTIMATE-TN', for non-metastatic TNBC. • The tool quantifies risks of BCSM, non-BCSM, and all-cause mortality. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BREAST tumor diagnosis
*EXPERIMENTAL design
*DATABASES
*CONFIDENCE intervals
*RESEARCH methodology
*METASTASIS
*TUMOR classification
*RISK assessment
*DESCRIPTIVE statistics
*DECISION making in clinical medicine
*DEATH
*BREAST tumors
*WOMEN'S health
*TUMOR grading
*SYMPTOMS
MORTALITY risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 09598049
- Volume :
- 189
- Database :
- Academic Search Index
- Journal :
- European Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 164855272
- Full Text :
- https://doi.org/10.1016/j.ejca.2023.05.018