Cutaneous adverse reactions to antiepileptic drugs: 17 cases at the Dermatology Department of the Arrazi Hospital in Marrakech.

Background: Antiepileptics are among the drugs mainly implicated in cutaneous adverse drug reactions (CADRs). Materials and Methods: The aim of this case series was to study the epidemiological, clinical, evolutionary, and therapeutic profile of antiepileptic-drug-induced toxidermia and the most often incriminated antiepileptic drugs. Results: We collected seventeen cases of a CADR to antiepileptic drugs at the Dermatology Department of CHU Mohamed VI in Marrakech over a period of five years. The mean age was 42 years. The pattern of CADRs was as follows: DRESS syndrome in 52.9%, Stevens-Johnson syndrome in 23.5%, Lyell syndrome in 11.8%, and acute generalized exanthematous pustulosis and fixed bullous generalized drug eruption in 5.9% each. Carbamazepine was the most often incriminated antiepileptic drug. Conclusion: CADRs to antiepileptic drugs are dominated by DRESS syndrome. Through this study, we underline the potential of antiepileptic drugs to induce serious toxidermia and that, therefore, their prescription must be reasoned. [ABSTRACT FROM AUTHOR]