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SARS-COV-2 spike protein fragment eases amyloidogenesis of α-synuclein.
- Source :
-
Journal of Chemical Physics . 7/7/2023, Vol. 159 Issue 1, p1-9. 9p. - Publication Year :
- 2023
-
Abstract
- Parkinson's disease is accompanied by the presence of amyloids in the brain that are formed of α-synuclein chains. The correlation between COVID-19 and the onset of Parkinson's disease led to the idea that amyloidogenic segments in SARS-COV-2 proteins can induce aggregation of α-synuclein. Using molecular dynamic simulations, we show that the fragment FKNIDGYFKI of the spike protein, which is unique for SARS-COV-2, preferentially shifts the ensemble of α-synuclein monomer toward rod-like fibril seeding conformations and, at the same time, differentially stabilizes this polymorph over the competing twister-like structure. Our results are compared with earlier work relying on a different protein fragment that is not specific for SARS-COV-2. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALPHA-synuclein
*SARS-CoV-2
*PARKINSON'S disease
*PROTEINS
*DYNAMIC simulation
Subjects
Details
- Language :
- English
- ISSN :
- 00219606
- Volume :
- 159
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Chemical Physics
- Publication Type :
- Academic Journal
- Accession number :
- 164785160
- Full Text :
- https://doi.org/10.1063/5.0157331