Increased bioavailability of diosmetin-7-glucoside-γ-cyclodextrin inclusion complex compared with diosmin in Sprague-Dawley rats.

Diosmin (DSN) is found mainly in citrus fruits, and has potent antioxidant effects. This study aimed to evaluate pharmacokinetics of diosmetin-7-glucoside-γ-cyclodextrin (DIOSG-CD) inclusion complex. The area under the curve values from AUC 0 - 24 of DIOSG-CD, prepared by reacting DSN and naringinase with γ -CD, were approximately 800-fold higher than those of DSN following their administration in Sprague-Dawley rats. [ABSTRACT FROM AUTHOR]