Characteristics of intracranial infection in patients after neurosurgery, and the influence of rational use of antibiotics.

Purpose: To investigate the characteristics of intracranial infection (ICI) in patients after neurosurgery, and the influence of rational use of antibiotics. Methods: The medical records of 127 patients with neurosurgery-related ICI who were admitted into Jincheng People's Hospital, Jincheng, Shanxi, China from April 2019 to April 2022 were selected. The results of bacterial culture and drug susceptibility tests of cerebrospinal fluid were collected, and the profile of bacteria in the cerebrospinal fluid specimens of patients and the different bacterial compositions were analyzed. Results: A total of 148 strains of pathogenic bacteria were cultured and isolated from the cerebrospinal fluid samples of 127 patients, out of which 91 strains of Gram-positive bacteria accounted for 61.49 %, and 57 strains of Gram-negative bacteria accounted for 38.51 %. The Gram-positive bacteria were Staphylococcus aureus, coagulase-negative Staphylococcus, and hemolytic Staphylococcus, while the Gram-negative bacteria comprised the pathogenic bacteria Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The Gram-positive bacteria were more sensitive to rifampicin (91.21 %), vancomycin (95.60 %), and linezolid (97.80 %), while the Gram-negative bacteria were more sensitive to imipenem (84.21 %), meropenem (75.44 %) and amikacin (77.19 %). Conclusion: Gram-positive bacteria are the main pathogenic bacteria implicated in ICI after neurosurgery in patients. A further large-scale study is needed for better delineation of the disease presentation and prognosis. [ABSTRACT FROM AUTHOR]