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ثرهشت هفته تمرینورزشیمقاومتی–استقامتی به همراه مصرف مکمل آویشنبر سطحANGPTL8،ICAM-1وVCAM-1 مرداندارای اضافه وزن وچاقغیرفعال:یک مطالعه کارآزمایی بالینی.

ثرهشت هفته تمرینورزشیمقاومتی–استقامتی به همراه مصرف مکمل آویشنبر سطحANGPTL8،ICAM-1وVCAM-1 مرداندارای اضافه وزن وچاقغیرفعال:یک مطالعه کارآزمایی بالینی.

Authors :
آرش صادقی
دکتر ماندانا غلا
دکتر حسن متین هم&#1575
دکتر حسین عابد ن&#1591
دکتر فرشاد غزالی
Source :
Journal of Gorgan University of Medical Sciences. Spring2023, Vol. 25 Issue 1, p1-10. 10p.
Publication Year :
2023

Abstract

Background and Objective: Exercise training and Zataria multiflora have a positive effect on health and can modulate cardiovascular risk factors. Adipose tissue-derived factors such as ANGPTL8 and adhesive molecules play an important role in exerting the pathological effects of obesity. This study aimed to investigate the effect of eight weeks of resistanceendurance exercise training combined with Zataria multiflora ingestion on the levels of ANGPTL8, ICAM-1, and VCAM-1 in sedentary overweight and obese men. Methods: In this clinical trial study, 40 sedentary overweight and obese men (with an average body mass index of 28.41±1.75 kg/m2) were randomly assigned to four groups with 10 subjects each. The groups included placebo, Zataria multiflora, training, and training + Zataria multiflora. The exercise training was combined training consisting of resistanceendurance exercise, conducted three times per week over eight weeks. Zataria multiflora supplement consumption was set at 500 mg daily. Blood sampling was conducted before and after the eight-week intervention, and the levels of ANGPTL8, ICAM-1, and VCAM-1 were measured using the ELISA method. Results: A significant decrease in serum levels of ANGPTL8 was observed in the training and training + Zataria multiflora groups compared to the placebo and Zataria multiflora groups (P<0.05). A decrease in serum ICAM-1 levels was significant in the training + Zataria multiflora group compared to the placebo group (P<0.05). Statistically significant decreases in serum VCAM-1 levels were observed in the training and training + Zataria multiflora groups compared to the placebo and training + Zataria multiflora groups (P<0.05). Conclusion: Zataria multiflora consumption, along with combined training, can have a synergistic effect in decreasing ANGPTL8, ICAM-1, and VCAM-1 levels. [ABSTRACT FROM AUTHOR]

Details

Language :
Persian
ISSN :
15624765
Volume :
25
Issue :
1
Database :
Academic Search Index
Journal :
Journal of Gorgan University of Medical Sciences
Publication Type :
Academic Journal
Accession number :
164710762