瑞巴派特四联疗法对幽门螺杆菌阳性消化性溃疡患者 血清氧化应激指标和胃蛋白酶原的影响.

Objective: To observe the efficacy of ouadruple therapy of rebamipide on helicobacter pylori (Hp) positive peptic ulcer and its influence on serum oxidative stress index and pepsinogen. Methods: Patients with Hp-positive peptic ulcer (n=100) who were admitted to Chest Hospital of Guangxi Zhuang Autonomous Region from July 2020 to December 2021 were selected, and they were divided into combination group (50 cases, ouadruple therapy of rebamipide) and control group (50 cases, standard ouadruple therapy) according to random number table method. Efficacy, scoring scale, serum oxidative stress index, pepsinogen (PG), incidence of adverse reactions, Hp eradication rate and recurrence rate were compared in the two groups. Results: The total clinical effective rate in the combination group was higher than that in the control group(P<0.05). The healing rate of peptic ulcer in the combination group was higher than that in the control group (P<0.05). After treatment, the scores of the Symptom Frequency Scale of Gastroesophageal reflux disease (FSSG) and clinical symptoms in the combination group were lower than those in the control group(P<0.05). After treatment, serum malondialdehyde (MDA) in the combination group was lower than that in the control group, and serum glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD) in the combination group were higher than those in the control group(P<0.05). After treatment, pepsinogen (PG) Ⅰ and PG Ⅱ in the combination group were lower than those in the control group (P<0.05). There was no difference in the total incidence of adverse reactions in the two groups (P>0.05). The Hp eradication rate in the combination group was higher than that in the control group, and the recurrence rate was lower than that in the control group(P<0.05). Conclusion: In the treatment of patients with Hp-positive peptic ulcer, ouadruple therapy of rebamipide can effectively promote ulcer healing, relieve clinical symptoms, improve the stress state of the body and the level of pepsinogen, increase the Hp eradication rate, reduce adverse reactions and recurrence. [ABSTRACT FROM AUTHOR]