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Cerebral amyloid angiopathy: clinical presentations and management challenges in the Australian context.

Authors :
Swarup, Oshi
Barker, James L.
Watson, Rosie
Davis, Stephen M.
Campbell, Bruce C. V.
Yassi, Nawaf
Source :
Internal Medicine Journal. Jun2023, Vol. 53 Issue 6, p907-916. 10p.
Publication Year :
2023

Abstract

Cerebral amyloid angiopathy (CAA) is a disease with several clinical manifestations. It is characterised by amyloid‐beta deposition in cerebral blood vessels, making them prone to bleeding. The incidence of CAA increases with age and may be associated or co‐exist with intraparenchymal neurodegenerative proteinopathies, which makes it an increasingly relevant condition for adult physicians in all areas of medical practice. The vast majority of cases of CAA are sporadic with a small minority of familial cases. CAA is asymptomatic in many older adults but increases the risk of fatal intracerebral or subarachnoid haemorrhage. We review the existing literature on CAA and summarise the key findings. We specifically explore clinical challenges relevant to CAA, particularly in diagnosis, management of intracranial haemorrhage and management of concurrent medical conditions. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14440903
Volume :
53
Issue :
6
Database :
Academic Search Index
Journal :
Internal Medicine Journal
Publication Type :
Academic Journal
Accession number :
164480718
Full Text :
https://doi.org/10.1111/imj.15999