腎細胞癌骨転移に伴う AA アミロイドーシスを発症した一例.

A 72-year-old woman was urgently hospitalized with a diagnosis of enteritis and subileus. Her past history was as follows. Right radical nephrectomy had been performed 14 years ago, and the pathological diagnosis was clear cell carcinoma (G2>G3). Four years later, she suffered from mulitiple lung and bone metastases and had been treated with a total of 7 courses of combination therapy with sorafenib and S-1, but the disease progressed within 1 year. Then, axitinib was started, and this stabilized her disease for 9 years. Watery stools and hypoalbuminemia continued even after quitting axitinib. A small bowel biopsy was performed, and she was diagnosed with protein-losing gastroenteropathy associated with AA amyloidosis. Gallium scintigraphy showed accumulation in the femur, and she was diagnosed with AA amyloidosis associated with bone metastasis of renal cell carcinoma. Radiation therapy to the femur relieved her symptoms just temporarily. She died of the disease one week later. AA amyloidosis belongs to systemic amyloidosis and is a disease in which amyloid protein is deposited in organs and causes damage. Cancer-related systemic amyloidosis accounts for seven percent of the total cases, and renal cell carcinoma is the most common among solid tumors. Control of the primary disease is most important for calming the symptoms of amyloidosis. [ABSTRACT FROM AUTHOR]