Theoretical Analysis of Sequencing Bioinformatics Algorithms and Beyond: A case study reveals the theoretical analysis of algorithms is not always as helpful as standard dogma might suggest.

This article discusses the use of theoretical analysis to measure the performance of algorithms and investigates its shortcomings using the field of sequencing bioinformatics. The author posits that theoretical analysis applied to algorithm performance has fallen short of its stated goals of predicting the empirical performance of an algorithm and being a yardstick to drive the design of new algorithms.