盆腔器官脱垂患者阴道微环境与 HPV 感染的相关性研究进展.

With the aging of the population and the improvement of people′s living standards, the prevalence of pelvic organ prolapse (POP) is increasing year by year. In the diagnosis and treatment of POP patients, it is not difficult to find cases with human papilloma virus (HPV) infection and cervical lesions. This article reviewed the correlation between the changes of vaginal microenvironment and HPV infection in POP patients. The results showed that POP patients were more likely to suffer from vaginitis due to the long-term exposure of prolapsed pelvic floor organs and tissues to the surrounding unclean environment. At the same time, the vaginal microenvironment changed significantly due to the decrease of estrogen level, the decrease of lactobacillus number, the increase of vaginal potential of hydrogen (PH) value, the decrease of systemic immunity and local immunity in the vagina. The combination of these factors may increase the risk of POP patients infected with high-risk HPV. Persistent high-risk HPV infection is a high-risk factor leading to cervical cancer, and cervical cancer is one of the three malignant tumors with the highest mortality rate among women, which seriously threatens the health of women. Therefore, in the clinical treatment of POP patients, attention should be paid to the health management of their vaginal microenvironment to prevent serious consequences caused by HPV infection, and further improve the quality of life of patients. [ABSTRACT FROM AUTHOR]