First electrochemical investigation of new generation antineoplastic agent ceritinib at a boron-doped diamond electrode based on the pre-enrichment effect of anionic surfactant.

In the present study, the first electrochemical investigation of ceritinib, which is a small-molecule tyrosine kinase inhibitor used as a new generation targeted anticancer drug, was described. For this purpose, a commercially available boron-doped diamond electrode pretreated cathodically was used. Using cyclic voltammetry, ceritinib presented two pairs of oxidation/reduction peaks in aqueous solution. The electrode process is controlled by a mixed diffusion and adsorption mechanism. The effects of pH and nature of the supporting electrolyte in the absence and the presence of anionic surfactant, sodium dodecylsulfate (SDS), pre-concentration variables and other instrumental parameters were demonstrated on the current response of ceritinib. It was observed that the addition of 8 × 10−4 mol L−1 SDS to the ceritinib solution prepared in 0.1 mol L−1 HNO3 improved the sensitivity of the stripping voltammetric measurements. By applying square-wave adsorptive stripping voltammetry (after 30 s pre-concentration at open-circuit condition), the calibration curves were linear for both oxidation peaks, Ia (at ~ + 0.99 V) and IIa (at ~ + 1.20 V) in the concentration range from 0.075 to 2.0 µg mL−1 (1.34 × 10−7–3.58 × 10−6 mol L−1), with detection limits of 0.014 µg mL−1 (2.50 × 10−8 mol L−1) for Ia, and 0.011 µg mL−1 (1.97 × 10−8 mol L−1) for IIa. The applicability of the developed methodology using the electrochemical signal IIa was verified by analysis of commercial capsule formulations and model human urine samples. [ABSTRACT FROM AUTHOR]