Production of singlet oxygen from photosensitizer erythrosine for facile inactivation of coronavirus on mask.

[Display omitted] • 10 μM Erythrosine reduced the coronavirus titer by more than 99.999% within 30 min. • Erythrosine inactivated the virus by producing singlet oxygen induced by light. • The color loss of erythrosine can indicate the complete inactivation of the virus. • The filtration efficiency of the mask remained at > 95% after erythrosine treatment. The global health crisis caused by the COVID-19 pandemic has led to a surge in demand and use of personal protective equipment (PPE) such as masks, putting great pressure on social production and the environment. It is urgent to find an efficient and non-destructive disinfection method for the safe reuse of PPE. This study proposes a PPE disinfection method that uses erythrosine, a U.S. Food and Drug Administration-approved food dye, as photosensitizer to produce singlet oxygen for virus inactivation, and indicates the completion of disinfection by its photobleaching color change. After spraying 100 μL of 10 μM erythrosine on the surface of the mask for 3 times and light exposure for 25 min, the titer of coronavirus decreased by more than 99.999%, and the color of erythrosine on the mask surface disappeared. In addition, the structure of the mask was intact and the filtration efficiency was maintained at > 95% after 10 cycles of erythrosine treatment. Therefore, this disinfection method can provide at least 10 cycles of reuse with the advantages of high safety and convenient, and the completion of disinfection can be indicated by its photobleaching, which is suitable for hospitals and daily life to reduce the consumption of PPE. [ABSTRACT FROM AUTHOR]