Back to Search Start Over

High-risk antibiotics positively correlated with antibiotic resistance genes in five typical urban wastewater.

Authors :
Sun, Shaojing
Wang, Qing
Wang, Na
Yang, Shengjuan
Qi, Hong
Source :
Journal of Environmental Management. Sep2023, Vol. 342, pN.PAG-N.PAG. 1p.
Publication Year :
2023

Abstract

Antibiotic resistance genes (ARGs) and antibiotic amount increased within close proximity to human dominated ecosystems. However, few studies assessed the distribution of antibiotics and ARGs in multiple ecosystems especially the different urban wastewater. In this study, the spatial distribution of ARGs and antibiotics across the urban wastewater included domestic, livestock, hospital, pharmaceutical wastewater, influent of the wastewater treatment plant (WWTP) in Northeast China. The q-PCR results showed that ARGs were most abundant in community wastewater and followed by WWTP influent, livestock wastewater, pharmaceutical wastewater and hospital wastewater. The ARG composition differed among the five ecotypes with qnr S was the dominant ARG subtypes in WWTP influent and community wastewater, while sul 2 dominant in livestock, hospital, pharmaceutical wastewater. The concentration of antibiotics was closely related to the antibiotic usage and consumption data. In addition to the high concentration of azithromycin at all sampling points, more than half of the antibiotics in livestock wastewater were veterinary antibiotics. However, antibiotics that closely related to humankind such as roxithromycin and sulfamethoxazole accounted for a higher proportion in hospital wastewater (13.6%) and domestic sewage (33.6%), respectively. The ambiguous correlation between ARGs and their corresponding antibiotics was detected. However, antibiotics that exhibited high ecotoxic effects were closely and positively correlated with ARGs and the class 1 integrons (intI 1), which indicated that high ecotoxic compounds might affect antimicrobial resistance of bacteria by mediating horizontal gene transfer of ARGs. The coupling mechanism between the ecological risk of antibiotics and bacterial resistance needed to be further studied, and thereby provided a new insight to study the impact of environmental pollutants on ARGs in various ecotypes. [Display omitted] • Total ARG abundance was highest in community wastewater. • Qnr S dominant in INF and CM samples, while sul 2 dominant in other ecotypes. • The spatial distribution of antibiotics related to the production and usage volumes. • Chronic toxicity presented high risk for AZI, ROX and SD. • Coupling mechanism occurred between bacterial resistance and ecological risk. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03014797
Volume :
342
Database :
Academic Search Index
Journal :
Journal of Environmental Management
Publication Type :
Academic Journal
Accession number :
164378838
Full Text :
https://doi.org/10.1016/j.jenvman.2023.118296