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De novo lupus nephritis after SARS-CoV-2 infection.
- Source :
-
Lupus . Jun2023, Vol. 32 Issue 7, p893-899. 7p. 2 Charts. - Publication Year :
- 2023
-
Abstract
- The relationship between viral infection and onset of autoimmune diseases such as systemic lupus erythematosus remains uncertain. During the COVID-19 pandemic, organ-specific and multisystemic autoimmune phenomena temporally related to the viral infection have been described. Immune dysregulation triggered by the SARS-CoV-2 virus leading to hyperactivation of both the innate and adaptive immune systems contributes to the excessive production of pro-inflammatory cytokines, autoantibodies, and subsequent autoimmune manifestations. We report two patients without known autoimmune diseases who developed lupus nephritis shortly after a documented mild SARS-CoV-2 infection. Together with other similar cases in the literature, the observation supports a viral trigger of the development of systemic lupus erythematosus in susceptible individuals. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09612033
- Volume :
- 32
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Lupus
- Publication Type :
- Academic Journal
- Accession number :
- 164374930
- Full Text :
- https://doi.org/10.1177/09612033231175280