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Ursolic Acid Derivatives Bearing 1,2,3-triazole Moieties as Potential PTP1B Inhibitors.
- Source :
-
Chemistry of Natural Compounds . May2023, Vol. 59 Issue 3, p508-511. 4p. - Publication Year :
- 2023
-
Abstract
- Here, a series of ursolic acid (UA) derivatives were identified as potential PTP1B enzyme inhibitors. All of the tested compounds showed potent PTP1B inhibitory activity (87.79–96.80%) at a concentration of 20 μg/mL and dose-dependently inhibited PTP1B enzyme with IC50 values ranging from 4.15 ± 0.01 to 14.10 ± 0.45 μM. Compound 11e showed the best PTP1B inhibitory potency, with IC50 values of 4.15 ± 0.01 μM, which was slightly lower than that of the positive control. Molecular docking simulation and analysis suggested that compound 11e has a good binding interaction with the active pocket. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00093130
- Volume :
- 59
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Chemistry of Natural Compounds
- Publication Type :
- Academic Journal
- Accession number :
- 164373043
- Full Text :
- https://doi.org/10.1007/s10600-023-04037-0