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Demographic inequities exist and influence transplant outcomes in liver transplantation for acute alcohol-associated hepatitis.

Authors :
Samuel, Sonia
Choubey, Ankur
Koizumi, Naoru
Ekwenna, Obi
Baxter, Patrick R.
Li, Meng-Hao
Malik, Raza
Ortiz, Jorge
Source :
HPB. Jul2023, Vol. 25 Issue 7, p845-854. 10p.
Publication Year :
2023

Abstract

Liver transplantation has inherent disparities but data is scarce in liver transplant (LT) candidates with acute alcohol-associated hepatitis (AAH). We aimed to investigate demographic inequities and its impact on survival outcomes among AAH LT candidates. A retrospective analysis using the United Network of Organ Sharing database was conducted between 2000 and 2021. 25 981 LT recipients with alcohol-associated liver cirrhosis and 662 recipients with AAH were included. Waitlisted candidates were also evaluated. In comparison with alcohol-associated liver cirrhosis, AAH LT recipients were more likely Asian or "other" race and younger. Hispanics demonstrated better graft and patient survival (p < 0.05) but were less likely to be waitlisted and transplanted for AAH than for liver cirrhosis. Women with AAH were more likely to be waitlisted and transplanted. Pre-existing diabetes and male sex were associated with higher graft failure (25% and 8% respectively). Increasing recipient age were 2% more likely to experience negative outcomes. Chronicity of liver disease did not impact graft (p = 0.137) or patient survival (p = 0.145). Our results revealed demographic factors have a significant impact on transplant listing, organ allocation and survival outcomes. Further investigations are imperative to minimize disparities in LT evaluation and provide equity in healthcare. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1365182X
Volume :
25
Issue :
7
Database :
Academic Search Index
Journal :
HPB
Publication Type :
Academic Journal
Accession number :
164300813
Full Text :
https://doi.org/10.1016/j.hpb.2023.04.002