Cyclometalated platinum(II) complex as a selective light switch for G-quadruplex DNA.

Authors :: Saini, Meenaxi
Keyes, Tia E.
Source :: Dalton Transactions: An International Journal of Inorganic Chemistry. 6/21/2023, Vol. 52 Issue 23, p7787-7791. 5p.
Publication Year :: 2023
Abstract: Cyclometalated 1,3-bis(8-quinolyl) phenyl chloroplatinum(II) (Pt1) shows selective luminescence transduction of G-quadruplex binding over duplex DNA. The effect is enhanced on association with parallel and hybrid G-quadruplex structures over other topologies. The kinetics of binding are studied for c-myc and the response is found to be partially reversible in a displacement assay. [ABSTRACT FROM AUTHOR]

Subjects :: *PLATINUM
*DNA
*LUMINESCENCE
*GENETIC transduction
*QUADRUPLEX nucleic acids
*TOPOLOGY

Language :: English
ISSN :: 14779226
Volume :: 52
Issue :: 23
Database :: Academic Search Index
Journal :: Dalton Transactions: An International Journal of Inorganic Chemistry
Publication Type :: Academic Journal
Accession number :: 164283672
Full Text :: https://doi.org/10.1039/d3dt01188g

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