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Green synthesized Ag nanoparticles decorated on the surface of Hibiscus tea leaf extract modified reduced graphene oxide: Investigation of its anti-lung carcinoma effects.
- Source :
-
South African Journal of Botany . Jul2023, Vol. 158, p190-196. 7p. - Publication Year :
- 2023
-
Abstract
- Eco-friendly green synthesized Ag NPs decorated on the surface of graphene oxide (RGO/Ag NPs) have been described using Hibiscus tea leaf extract. The Hibiscus tea leaf extract was applied as a reducing and stabilizing agent for immobilizing silver nanoparticles without aggregation with spherical shape and uniform sizes. The as-synthesized nanocomposite (RGO/Ag NPs) was characterized using FE-SEM, EDX, elemental mapping, TEM, XRD and ICP analysis. The synthesized nanocomposite had very low cell viability and high anti-lung carcinoma activities dose-dependently against HLC-1, PC-14, LC-2/ad and NCI-H322 cell lines without any cytotoxicity on the normal cell line (HUVEC). The IC50 of the nanocomposite were 500, 327, 204, and 542 µg/mL against HLC-1, PC-14, LC-2/ad and NCI-H322 cell lines, respectively. The synthesized nanocomposite inhibited half of the DPPH molecules in the concentration of 141 µg/mL. Perhaps notable anti-lung carcinoma activities of the synthesized nanocomposite against common lung carcinoma cell lines are linked to their antioxidant activities. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02546299
- Volume :
- 158
- Database :
- Academic Search Index
- Journal :
- South African Journal of Botany
- Publication Type :
- Academic Journal
- Accession number :
- 164282010
- Full Text :
- https://doi.org/10.1016/j.sajb.2023.04.051