硫氧还蛋白相互作用蛋白在多囊卵巢综合征中作用的研究进展.

Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disease commonly in women of reproductive age, characterized by irregular menstruation, hyperandrogenemia and polycystic ovary changes, often manifested as obesity, infertility and insulin resistance. Thioredoxin-interacting protein (TXNIP) is a multifunctional regulator that is not only involved in the regulation of insulin secretion and glucose metabolism, but also closely related to oxidative stress, inflammatory factors and mood disorders. Studies have shown that TXNIP levels are significantly increased in PCOS patients, suggesting that TXNIP may be involved in the development of PCOS and its complications. In recent years, some in vivo and ex vivo studies have attempted to use herbal extracts and western drugs to inhibit TXNIP expression, and the discovery of TXNIP-specific inhibitors makes it a promising and effective target to inhibit the process of PCOS. This article reviews the role of TXNIP in PCOS, in order to provide new ideas and directions for the in-depth study of PCOS pathogenesis and its clinical diagnosis and treatment. [ABSTRACT FROM AUTHOR]