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Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2019–2020: General view of the pathogens' antibacterial susceptibility

Authors :
Tokimatsu, Issei
Matsumoto, Tetsuya
Tsukada, Hiroki
Fujikura, Yuji
Miki, Makoto
Morinaga, Yoshitomo
Sato, Junko
Wakamura, Tomotaro
Kiyota, Hiroshi
Tateda, Kazuhiro
Yanagisawa, Hideji
Sasaki, Takaaki
Ikeda, Hideki
Horikawa, Hiroshi
Takahashi, Hiroshi
Seki, Masafumi
Mori, Yoshiaki
Takeda, Hiroaki
Kurai, Daisuke
Hasegawa, Naoki
Source :
Journal of Infection & Chemotherapy (Elsevier Inc.). Aug2023, Vol. 29 Issue 8, p731-743. 13p.
Publication Year :
2023

Abstract

The trends and prevalence of antimicrobial susceptibility of pathogens vary by country, region, and time. Long-term regular surveillance is required to investigate trends in the antimicrobial resistance of various isolated bacterial pathogens. We report the results of a nationwide surveillance on the antimicrobial susceptibility of bacterial respiratory pathogens in Japan conducted by the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology. The isolates were collected from clinical specimens obtained from adult patients who visited a collaborating medical facility between June 2019 and December 2020 and were diagnosed with respiratory tract infections by a physician. Antimicrobial susceptibility testing was performed in a centralized laboratory according to the methods recommended by the Clinical and Laboratory Standards Institute. Susceptibility testing was performed for 932 strains (201 Staphylococcus aureus , 158 Streptococcus pneumoniae , 6 S. pyogenes , 136 Haemophilus influenzae , 127 Moraxella catarrhalis , 141 Klebsiella pneumoniae , and 163 Pseudomonas aeruginosa) collected from 32 facilities in Japan. The proportions of methicillin-resistant S. aureus and penicillin-resistant S. pneumoniae were 35.3% and 0%, respectively. In H. influenzae , 16.2% and 16.9% were β-lactamase-producing ampicillin resistant and β-lactamase-negative ampicillin resistant, respectively. Extended-spectrum β-lactamase-producing K. pneumoniae accounted for 5.0% of all K. pneumoniae infections. Carbapenemase-producing K. pneumoniae and multi-drug-resistant P. aeruginosa with metallo-β-lactamase were not detected in this study. This surveillance will be a useful reference for treating respiratory infections in Japan and will provide evidence to enhance the appropriate use of antimicrobial agents. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1341321X
Volume :
29
Issue :
8
Database :
Academic Search Index
Journal :
Journal of Infection & Chemotherapy (Elsevier Inc.)
Publication Type :
Academic Journal
Accession number :
164255092
Full Text :
https://doi.org/10.1016/j.jiac.2023.04.008