Factors associated with suicide attempts in first-episode psychosis during the first two years after onset.

• Most suicide attempts in this sample of FEP patients occurred during the untreated psychosis period. • A personal history of suicide attempts was associated with a higher risk of suicide attempt. • The presence of depressive symptoms, especially feeling of guilt, was a significant risk factor for suicide attempts. • Poor functionality at baseline was associated with a higher risk of suicide attempts. • Early intervention in high-risk patients could play an important role in suicide prevention in early psychosis. The risk of suicide in first-episode psychosis (FEP) is high. However, there are many unknowns about this phenomenon and the risk factors associated with higher risk are not well-understood. Therefore, we aimed to determine the baseline sociodemographic and clinical factors associated with suicide attempts in FEP patients over two-years after psychosis onset. Univariate and logistic regression analyses were performed. Between April 2013 and July 2020, 279 patients treated at the FEP Intervention Program at our hospital (Hospital del Mar, Spain) were enrolled and 267 completed the follow-up. Of these, 30 patients (11.2%) made at least one suicide attempt, mostly during the untreated psychosis period (17 patients, 48.6%). Several variables—prior history of suicide attempts and low functionality, depression, and feelings of guilt at baseline—were all significantly associated with suicide attempts. These findings suggest that targeted interventions, especially in prodromal stages, could play a key role in identifying and treating FEP patients with a high suicide risk. [Display omitted] [ABSTRACT FROM AUTHOR]