The effect of Flaxseed intake on appetite control: A systematic review of Randomized Clinical Trials.

Background: Appetite control has attracted many scientists' attention recently since it contributes to weight management and the prevention of further metabolic disorders. Many studies have been done to assess the effect of flaxseed on satiety perception but the results are controversial. The aim of this study is to review these studies comprehensively (PROSPERO: CRD42021265751). Methods: Related articles were searched in PubMed/Medline, Web of Science, Scopus, and Cochrane databases on June 2021. No limitation was imposed in the search strategy. The keywords for appetite were visual analog scale, appetite, desire to eat, satiation, satiety, hunger, fullness and for Flaxseed they were flax, flax*, linseed*, lignin*, Linseed Oil, flaxseed, ground flaxseed, flaxseed oil, and Linum usitatissimum. Results: Thirteen papers were eligible to be included in this systematic review. These studies were inconsistent in results and some of them found no significant effect of flaxseed on appetite. However, three studies revealed a significant reduction in hunger perception as well as appetite, two studies found a decreasing effect on prospective consumption and three other studies observed a positive significant effect on fullness and satiety. Conclusion: Although there is a limited number of papers related to the effect of flaxseed on appetite perception or its equivalent terms, the available studies can suggest the potential role of flaxseed in decreasing appetite and hunger. More well-designed clinical randomized trials are necessary to prove this relationship more precisely. [ABSTRACT FROM AUTHOR]