Backward bifurcation, basic reinfection number and robustness of an SEIRE epidemic model with reinfection.

Recent evidences show that individuals who recovered from COVID-19 can be reinfected. However, this phenomenon has rarely been studied using mathematical models. In this paper, we propose an SEIRE epidemic model to describe the spread of the epidemic with reinfection. We obtain the important thresholds R 0 (the basic reproduction number) and R c (a threshold less than one). Our investigations show that when R 0 > 1 , the system has an endemic equilibrium, which is globally asymptotically stable. When R c < R 0 < 1 , the epidemic system exhibits bistable dynamics. That is, the system has backward bifurcation and the disease cannot be eradicated. In order to eradicate the disease, we must ensure that the basic reproduction number R 0 is less than R c . The basic reinfection number is obtained to measure the reinfection force, which turns out to be a new tipping point for disease dynamics. We also give definition of robustness, a new concept to measure the difficulty of completely eliminating the disease for a bistable epidemic system. Numerical simulations are carried out to verify the conclusions. [ABSTRACT FROM AUTHOR]