Molecularly imprinted membrane – Glucose synthesis with polyeugenol based for in-situ glucose transport.

Hemodialysis in patients with the diabetes-associated end-stage renal disease requires continuous blood glucose management. This is because glucose levels are very susceptible to change for diabetic patients while undergoing hemodialysis. So, in the hemodialysis membrane application, a glucose sensor is needed. The purpose of this study was to synthesized a glucose sensor named Molecularly Imprinted Membrane (MIM – Glucose) to determine the ability of polyeugenol in transporting glucose molecules. MIM - Glucose based on polyeugenol was crosslinked with Polyethylene glycol diethyl ether (PEGDE), and Polyvinyl Alcohol (PVA) was added. Transport glucose by MIM-glucose was compared with Non-imprinted Membrane (NIM) in PBS solution with pH 7,4. MIM-Glucose was varied with a membrane thickness of 0,23; 0,43; 1,03 mm. Glucose levels were determined by the 3-5 dinitrosalicylic acid (DNS) method. Characterization carried out in this study was Fourier-Transform Infrared (FTIR) spectrometer and Scanning Electron Microscope-Energy Dispersive X-Ray (SEM-EDX). MIM-Glucose with a membrane thickness of 0,23 mm showed the best performance in transporting glucose in comparison to NIM. The membrane with a thickness of 0.23 mm can transport 26.6% glucose in 24 hours. Those results are also supported by evaluating the porosity of MIM-Glucose which is better than NIM. [ABSTRACT FROM AUTHOR]