Can transcranial magnetic stimulation rescue dopaminergic signalling in Alzheimer's disease?

An I in vivo i SPECT imaging study[9] measured the binding of SP 123 sp I-FP-CIT to dopamine transporter (DAT) in patients with MCI due to AD and in AD patients. Early deficits, including episodic memory, are widely recognized in patients who suffer from mild cognitive impairment (MCI) due to Alzheimer disease (AD) and, in particular, the amnestic variant, (a-MCI). The precuneus and other areas of the posteromedial parietal cortex (PMC), synergizing with the frontal cortex, are primarily engaged during tasks that involve episodic memory, visuospatial working memory and visuomotor abilities. [Extracted from the article]