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Birth Weight, Gestational Age, and Risk of Cardiovascular Disease in Early Adulthood: Influence of Familial Factors.
- Source :
-
American Journal of Epidemiology . Jun2023, Vol. 192 Issue 6, p866-877. 12p. - Publication Year :
- 2023
-
Abstract
- The association between intrauterine growth restriction and cardiovascular disease (CVD) later in life might be confounded by familial factors. We conducted a binational register-based cohort study to assess associations of birth weight for gestational age (GA), a proxy for intrauterine growth restriction, and GA with CVD risk in early adulthood, before and after addressing familial factors via sibling comparison. We included 3,410,334 live nonmalformed singleton births from Sweden (1973–1996) and Denmark (1978–1998). During a median follow-up period of 10 years from age 18 years onwards, 29,742 individuals developed incident CVD (hypertension, ischemic heart disease, or cerebrovascular disease). Compared with individuals born with appropriate birth weight for GA (AGA; 10th–90th percentiles) or full term (39–40 gestational weeks), individuals born severely small for GA (SGA; ≤3rd percentile) or preterm (22–36 weeks) were at increased risk of CVD (hazard ratio (HR) = 1.38 (95% confidence interval (CI): 1.32, 1.45) and HR = 1.31 (95% CI: 1.25, 1.38), respectively). The association was attenuated when comparing individuals born SGA with their AGA siblings (HR = 1.11, 95% CI: 0.99, 1.25) but remained robust when comparing individuals born preterm with their term siblings (HR = 1.21, 95% CI: 1.07, 1.37). Our findings suggest that both SGA and preterm birth are associated with CVD risk in early adulthood, with greater familial confounding noted for SGA birth. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYPERTENSION epidemiology
*PREMATURE infants
*CEREBROVASCULAR disease
*STROKE
*CONFIDENCE intervals
*MYOCARDIAL ischemia
*GESTATIONAL age
*CARDIOVASCULAR diseases
*FETAL growth retardation
*DISEASE incidence
*RISK assessment
*COMPARATIVE studies
*BIRTH weight
*DESCRIPTIVE statistics
*ODDS ratio
*LONGITUDINAL method
*ADULTS
Subjects
Details
- Language :
- English
- ISSN :
- 00029262
- Volume :
- 192
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- American Journal of Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 164082886
- Full Text :
- https://doi.org/10.1093/aje/kwac223