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Asociación de la relación neutrófilos, linfocitos y plaquetas con lesión renal aguda en sepsis.

Authors :
Bravo-Santibáñez, Edgar
Alicia Hernández-González, Martha
López-Briones, Sergio
Contreras-Chávez, Marisol
Source :
Revista Medica del IMSS. may/jun2023, Vol. 61 Issue 3, p342-347. 6p.
Publication Year :
2023

Abstract

Background: Acute kidney injury (AKI) is frequent in sepsis (25 to 51%), with high mortality (40 to 80%) and long-term complications. Despite its importance we do not have accessible markers in intensive care. In other entities (post-surgical and COVID-19) the neutrophil/lymphocyte and platelet (N/LP) ratio has been associated with acute kidney injury; however, this relationship has not been studied in a pathology with a severe inflammatory response such as sepsis. Objective: To demonstrate the association between N/LP with AKI secondary to sepsis in intensive care. Material and methods: Ambispective cohort study in patients over 18 years who were admitted to intensive care with a diagnosis of sepsis. The N/LP ratio was calculated from admission up to the seventh day and up to the diagnosis of AKI and outcome. Statistical analysis was performed with chi squared test, Cramer's V and multivariate logistic regression. Results: Out of the 239 patients studied, the incidence of AKI developed in 70%. 80.9% of patients with N/LP ratio > 3 had AKI (p < 0.0001, Cramer's V 0.458, OR 3.05, 95% CI 1.602-5.8) and increased renal replacement therapy (21.1 vs. 11.1%, p = 0.043). Conclusion: N/LP ratio > 3 has a moderate association with AKI secondary to sepsis in the intensive care unit. [ABSTRACT FROM AUTHOR]

Details

Language :
Spanish
ISSN :
04435117
Volume :
61
Issue :
3
Database :
Academic Search Index
Journal :
Revista Medica del IMSS
Publication Type :
Academic Journal
Accession number :
164034116