Progression of Cardiac Abnormalities in Hutchinson-Gilford Progeria Syndrome: A Prospective Longitudinal Study.

Seven patients (16%) had nonspecific ST-segments or T-wave abnormalities, 9 patients (20%) had LV hypertrophy, and 2 patients (5%) had a prolonged QTc interval. Two patients (5%) had nonspecific ST-segment or T-wave abnormalities, 7 patients (16%) had LV hypertrophy, and 1 patient had an intraventricular conduction abnormality. Keywords: disease progression; progeria; ventricular dysfunction; left EN disease progression progeria ventricular dysfunction left 1782 1784 3 06/02/23 20230606 NES 230606 Hutchinson-Gilford Progeria syndrome (HGPS) is an ultrarare systemic disorder that causes accelerated aging and premature death, often due to cardiovascular disease.[1],[2] Because of its rarity, the characterization of cardiac abnormalities has been limited to cross-sectional assessment of small cohorts, and data on the progression of these abnormalities are lacking.[3] As a follow-up to our previous cross-sectional report, we evaluated longitudinal changes in cardiac abnormalities in patients with HGPS. [Extracted from the article]