Dupilumab reduces symptom burden in allergic rhinitis and suppresses allergen‐specific IgE production.

Dupilumab reduces symptom burden in allergic rhinitis and suppresses allergen-specific IgE production Keywords: allergen-specific; allergy; birch pollen; dupilumab; grass pollen EN allergen-specific allergy birch pollen dupilumab grass pollen 1687 1691 5 06/02/23 20230601 NES 230601 To the Editor, Type 2 immune responses underlie many respiratory diseases including allergy and chronic rhinosinusitis. In some patients, allergen-specific IgE levels in nMLF dropped even below the detection limit (e.g. patient #1, 2 and #3 for selected allergens). Male patients experienced on average a larger reduction in total IgE in nMLF but not in serum and the percentage reduction in serum IgE levels correlated negatively with the number of allergens a patient was sensitised to (Tables S2 and S3). [Extracted from the article]