Loss of PP4 contributes to diesel exhaust particles‐induced epithelial barrier integrity disruption and alarmins release.

Bronchial specimens from patients with well-controlled asthma who had more intact airway epithelium were used for comparison with specimens from patients with severe asthma. Severe asthma: PP4 expression in the denuded epithelium of patients with severe asthma was very low. Loss of PP4 contributes to diesel exhaust particles-induced epithelial barrier integrity disruption and alarmins release. [Extracted from the article]