A New Flavonoid Glycoside and Other Constituents from Sedum sarmentosum with Anti-Inflammatory Activity.

One new flavonol glycoside (1), together with one known flavonol glycoside (2) and 16 known megastigmanes (3–18) were isolated from the whole plant of Sedum sarmentosum Bunge. Their structures were established by spectroscopic data (1D, 2D NMR, and HR-ESI-MS) and comparison with the literature. Among them, compounds 8 and 10–12 were reported from the Crassulaceae family for the first time. Anti-inflammatory effects of the isolated compounds were evaluated in terms of inhibition of NO, TNF-α, and IL-6 production in lipopolysaccharide-stimulated RAW 264.7 cells. Compounds 8 and 16 could inhibit NO production with IC50 values of 47.93 ± 3.43 μM and 47.11 ± 3.63 μM. Compounds 4 and 6 showed an inhibitory effect on IL-6 production with IC50 values of 34.37 ± 4.84 μM and 38.26 ± 3.32 μM. [ABSTRACT FROM AUTHOR]