Dual-layer spectral CT improves the image quality of cerebral unenhanced CT scan in children.

To evaluate the image quality and determine the optimal energies of virtual monoenergetic imaging (VMI) in unenhanced pediatric cerebral scans by dual-layer spectral detector computed tomography (DLCT). Fifty-three consecutive unenhanced cerebral scans by a DLCT scanner in children (age ≤ 12 years) were retrospectively analyzed. Conventional images (CI) and VMIs were reconstructed. The gray matter (GM) and white matter (WM) noise, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), posterior fossa, and subcalvarial artifac tindex (PFAI, SAI) were calculated. Two radiologists independently determined the image quality using a 5-point Likert-type scale based on GM − WM differentiation (GWMA), subcalvarialspace (SAA), beam hardening artifacts in the posterior fossa (PFAA), and the overall diagnostic quality. The student t -test and Wilcoxon test were used to determining the statistical significance. Compared with CI, superior noise were observed in VMI at low keV levels and were lowest at 100 keV (P < 0.001); the SNR and CNR were significantly higher at the 45 keV to 75 keV levels (all Ps of <0.005). The best GWMA were noticed at the 50 keV level compared to other keV levels (all P < 0.05). The optimal SAA and PFAA were found at 100 keV, respectively. The assessment of overall diagnostic quality was the best at 50 keV (P < 0.013 to < 0.001). The VMI scan significantly improved the quality of pediatric cerebral images compared with those from CI. The optimal energy level for the brain parenchyma was 50 keV while those for subcalvarial space and posterior fossa were 100 keV. [ABSTRACT FROM AUTHOR]