Back to Search
Start Over
A broad overview of genotype imputation: Standard guidelines, approaches, and future investigations in genomic association studies.
- Source :
-
Biocell . 2023, Vol. 47 Issue 6, p1225-1241. 17p. - Publication Year :
- 2023
-
Abstract
- The advent of genomic big data and the statistical need for reaching significant results have led genome-wide association studies to be ravenous of a huge number of genetic markers scattered along the whole genome. Since its very beginning, the so-called genotype imputation served this purpose; this statistical and inferential procedure based on a known reference panel opened the theoretical possibility to extend association analyses to a greater number of polymorphic sites which have not been previously assayed by the used technology. In this review, we present a broad overview of the genotype imputation process, showing the most known methods and presenting the main areas of interest, with a closer look to the most up-to-date approaches and a deeper understanding of its usage in the presentday genomic landscape, shedding a light on its future developments and investigation areas. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GENOTYPES
*BIG data
*GENOME-wide association studies
*HAPLOTYPES
*GENETIC markers
Subjects
Details
- Language :
- English
- ISSN :
- 03279545
- Volume :
- 47
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Biocell
- Publication Type :
- Academic Journal
- Accession number :
- 163958178
- Full Text :
- https://doi.org/10.32604/biocell.2023.027884