One pot synthesis of phosphate glass with in situ formed nanodiamonds from adenosine triphosphate for bone repair.

Glasses and nanodiamonds have been widely used as biomaterials, particularly in orthopedics. Biomolecule-derived materials are also gaining popularity in biomedical applications. Therefore, a biomolecule-derived glass with in situ formed nanodiamonds could be interesting material. The biomolecule-derived glass obtained in this study was synthesized by melt-quenching adenosine triphosphate-disodium. According to spectroscopic studies such as Raman spectroscopy, FTIR, and XPS, the glass formed from the phosphate groups of ATP is predominantly made of metaphosphate. The TEM, XPS, and Raman spectroscopic analysis confirm the in situ conversion of the organic portion of the ATP molecule into nanodiamonds. The confocal microscopy also reveals the fluorescence property of the nanodiamonds. In vitro experiments further demonstrate that the glass is non-cytotoxic, bioactive, and angiogenic, implying that it could be used in bone repair. This study also establishes that phosphate glass supports nanodiamonds formation and that biomolecule can form glass and nanodiamonds under the right conditions. [ABSTRACT FROM AUTHOR]