Effects of Polysaccharides from Enteromorpha prolifera on Hepatorenal Syndrome in Mice.

[Objectives] This study was conducted to evaluate the protective effect of polysaccharides from Enteromorpha prolifera (PEP) on mice with hepatorenal syndrome induced by carbon tetrachloride. [Methods] A mouse hepatorenal syndrome model was induced by carbon tetrachloride. The serum levels of lipid, total antioxidant capacity, liver and kidney function, pathological changes of liver and kidney were selected to clarity the effectiveness of PEP on hepatorenal syndrome in mice. [Results] PEP effectively 10w ?ered the serum levels of lipid, increased total antioxidant capacity, improved liver and kidney injury, and alleviated pathological changes of liver and kidney of mice induced by carbon tetrachloride. [Conclusions] PEP has a potent preventive effect on hepatorenal syndrome induced by carbon tetrachloride in mice, which provides theoretical support for future clinical application of PEP. [ABSTRACT FROM AUTHOR]