Study of Coagulation Profile and Haematological Parameters in Patient Presenting With Preeclampsia and Eclampsia in the Tertiary Care Center - A Prospective Study.

Background: Pregnancy-induced hypertension (PIH) complicates about 6-10% of pregnancies around the world. According to the WHO, PIH is one of the leading causes of maternal, fetal, and neonatal mortality and morbidity. PIH causes many hematological aberrations in women and any abnormalities in the coagulation of blood lead to hemorrhages. Aim and objective: To Study the Changes in Hematological Parameters and Coagulation Profile and Correlate these Parameters in Preeclampsia and Eclampsia patients. Material and Methods: In this prospective study we studied Hematological Parameters(Platelet count, Neutrophil lymphocyte ratio )and Coagulation Profile (BT,CT,PT, aPTT, D-dimer)in 80 female presenting with pregnancy induced hypertension in a period of One & a half year admitted in Kamla Raja Hospital, Gajra Raja Medical College, Gwalior. Results: Out of 80 patient studied, 60 (75%) were Preeclampsia patient and 20 (25%) were Eclampsia patient. Age distribution was 19. -30 years. Most patient (52.5%) were in their third trimester. All patients show bleeding time and clotting time in normal range. Preeclampsia (13.75%) and eclampsia (12.5%) patients shows increased Prothrombin time. All Eclampsia patients showed D-dimer > 0.5 µgm/ dl FEU and thrombocytopenia. Neutrophil Lymphocyte Ratio increases as severity of PIH increases. Conclusion: Raised neutrophil lymphocyte ratio, D-dimer and thrombocytopenia are fairly good indicator of severe Preeclampsia, Eclampsia and needs aggressive treatment. [ABSTRACT FROM AUTHOR]