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Immune tolerance breakdown in inborn errors of immunity: Paving the way to novel therapeutic approaches.

Authors :
Giardino, Giuliana
Romano, Roberta
Lougaris, Vassilios
Castagnoli, Riccardo
Cillo, Francesca
Leonardi, Lucia
La Torre, Francesco
Soresina, Annarosa
Federici, Silvia
Cancrini, Caterina
Pacillo, Lucia
Toriello, Elisabetta
Cinicola, Bianca Laura
Corrente, Stefania
Volpi, Stefano
Marseglia, Gian Luigi
Pignata, Claudio
Cardinale, Fabio
Source :
Clinical Immunology. Jun2023, Vol. 251, pN.PAG-N.PAG. 1p.
Publication Year :
2023

Abstract

Up to 25% of the patients with inborn errors of immunity (IEI) also exhibit immunodysregulatory features. The association of immune dysregulation and immunodeficiency may be explained by different mechanisms. The understanding of mechanisms underlying immune dysregulation in IEI has paved the way for the development of targeted treatments. In this review article, we will summarize the mechanisms of immune tolerance breakdown and the targeted therapeutic approaches to immune dysregulation in IEI. • Immunodysregulatory features may be observed in about 25% of patients with Inborn errors of immunity. • The association of immune dysregulation and immunodeficiency may be explained by different mechanisms. • The identification of the pathogenetic mechanisms has led to the development of precision treatments. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
15216616
Volume :
251
Database :
Academic Search Index
Journal :
Clinical Immunology
Publication Type :
Academic Journal
Accession number :
163820891
Full Text :
https://doi.org/10.1016/j.clim.2023.109302