踝关节骨关节炎动物模型构建的研究与进展.

BACKGROUND: As a disease that greatly affects the quality of life of patients, ankle osteoarthritis has been paid more and more attention. The clinical and experimental research of ankle osteoarthritis is not as complete as that of knee joint, and there is a lack of systematic review on animal models. OBJECTIVE: To explore the methods and characteristics of experimental models of ankle osteoarthritis, and to provide theoretical basis for the improvement of experimental research of ankle osteoarthritis. METHODS: Using the search terms of “ankle joint, osteoarthritis, animal models, post-traumatic osteoarthritis”, CNKI, WANFANG Data Platform, VIP, PubMed, and Embase databases from 2009 to 2022 were searched. Totally 49 articles were included for systematic review. RESULTS AND CONCLUSION: (1) In the animal model of ankle osteoarthritis, the modeling methods for traumatic arthritis include chronic ankle instability model and intra-articular fracture model. Noninvasive animal models include intraarticular drug injection-induced models, cartilage atrophy models, joint senescence models, and spontaneous osteoarthritis models in specific strains of osteoarthritis susceptible species. (2) Although the incidence of traumatic ankle osteoarthritis is high, the research on ankle osteoarthritis is quite limited compared with knee osteoarthritis. Due to the differences in structure and characteristics between ankle joint and knee joint, the research results of knee joint are not completely applicable to ankle joint. The study of its animal model is more conducive to the in-depth exploration of the blind area of the current research. [ABSTRACT FROM AUTHOR]