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Spectroscopic Studies and In Vitro Antitumor Evaluation of Some New Hybrid Ethyl 2-Oxoquinoline-3-carboxylates and Their Halo Derivatives.
- Source :
-
Russian Journal of Organic Chemistry . Mar2023, Vol. 59 Issue 3, p438-444. 7p. - Publication Year :
- 2023
-
Abstract
- A series of new ethyl 7-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylates and their halogenated derivatives were synthesized. Ethyl 7-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate (2) was obtained by the condensation of 2-amino-4-hydroxybenzaldehyde and diethyl malonate. Halogenation of compound 2 with bromine led to the formation of 6,8-dibromo derivative 5, and the acylation and alkylation of 2 and 5 with acetic anhydride and p-chlorophenacyl bromide gave the corresponding acetoxy derivatives 3 and 6 and alkoxy derivatives 4 and 7. Compounds 2–7 were evaluated for their in vitro antiproliferative activity against MCF-7 and HepG2 cancer cell lines. The cell cycle analysis of compound 4 demonstrated cell cycle arrest at the G2/M phase and pre-G1 apoptosis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10704280
- Volume :
- 59
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Russian Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 163726538
- Full Text :
- https://doi.org/10.1134/S1070428023030119