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Cooperative phototherapy based on bimodal imaging guidance for the treatment of uveal melanoma.

Authors :
Huang, Tong
Xu, Xinzhi
Cheng, Chen
Wang, Jianxin
Yang, Liping
Source :
Journal of Nanobiotechnology. 5/4/2023, Vol. 21 Issue 1, p1-17. 17p.
Publication Year :
2023

Abstract

Background: Uveal melanoma (UM) is adults' most common primary intraocular malignant tumor, prone to metastasis and high mortality. Eyeball enucleation commonly used in the clinic will lead to permanent blindness and mental disorders. Thus, new methods are urgently needed to diagnose and treat UM early to preserve patients' vision. Methods and results: Herein, multifunctional nanoparticles (NPs) were synthesized by loading chlorin e6 (Ce6) in poly-lactic-co-glycolic acid (PLGA) NPs and wrapping FeIII-tannic acid (FeIII-TA) on the outside (FeIII-TA/PLGA/Ce6, designated as FTCPNPs). Then, the synergistic photothermal therapy (PTT) and photodynamic therapy (PDT) antitumor effects of FTCPNPs excited by near-infrared (NIR) laser were evaluated. Moreover, we verified the mechanism of synergistic PTT/PDT leading to mitochondrial dysfunction and inducing tumor cell apoptosis. Additionally, FTCPNPs can be used as excellent magnetic resonance (MR)/photoacoustic (PA) imaging contrast agents, enabling imaging-guided cancer treatment. Finally, The NPs have good biological safety. Conclusion: This noninvasive NIR light-triggered cooperative phototherapy can easily penetrate eye tissue and overcome the disadvantage of limited penetration of phototherapy. Therefore, cooperative phototherapy is expected to be used in fundus tumors. This treatment model is applied to UM for the first time, providing a promising strategy and new idea for integrating the diagnosis and treatment of UM. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14773155
Volume :
21
Issue :
1
Database :
Academic Search Index
Journal :
Journal of Nanobiotechnology
Publication Type :
Academic Journal
Accession number :
163523199
Full Text :
https://doi.org/10.1186/s12951-023-01891-6