One-pot synthesis of 2,6-diaryl-4,5-dihydropyridazin-3(2H)-ones: Copper catalyzed annulation of aldehydes, arylhydrazines and 3-acryloyloxazolidin-2-one.

[Display omitted] • The three-component starting materials are available aldehydes, arylhydrazines and 3-acryloyloxazolidin-2-one. • This strategy exhibits high tolerance towards many functional aldehydes. • The useful tetrahydropyridazines could be achieved in excellent yields by one-step reduction. The three-component synthesis of pyridazinones from aldehydes, arylhydrazines and 3-acryloyloxazolidin-2-one catalyzed by Cu(OTf) 2 has been developed. This strategy exhibits high tolerance towards many functional groups including various aliphatic, aromatic and hetero-aromatic aldehydes to give 2,6-diaryl-4,5-dihydropyridazin-3(2 H)-one products in moderate to high yields. [ABSTRACT FROM AUTHOR]