In this issue: Graphical Abstract.

Abbreviations: CIndU, chronic inducible urticaria; ColdU, cold urticaria; FcR, Fc receptor; Ig, immunoglobulin; KIT, KIT proto-oncogene, receptor tyrosine kinase; MC, mast cell; MRGPRX2, mas-related G protein-coupled receptor-X2; QoL, quality of life; SCF, stem cell factor; SD, symptomatic dermographism. Katie Bitting, Barry Hedgespeth, Lauren C. Ehrhardt-humbert, Greer K. Arthur, Alicia G. Schubert, Peter bradding, Stephen l. Tilley, Glenn Cruse We identify that MS4A6A is expressed in human mast cells and has high sequence homology to Fc RI . These changes were reversed by anti-IL-6 treatment ( I AL i -M + anti-IL-6) and phenocopy by adding rIL-6 alone. [Extracted from the article]