Comparative Determination of Immunobiochemical Indicators in Patients with Cardiovascular Diseases.

The development of new diagnostic methods for the prediction, treatment, and prevention of cardiovascular diseases is an urgent task. The purpose of this study was to compare specific immunological and clinical-biochemical markers in patients with cardiovascular diseases. In accordance with the established diagnosis, three groups of participants were examined, a total of 139 people, including the control group. The first group was patients with hypertension, the second group, had a diagnosis of hypertension and coronary heart disease. In these patients, biochemical parameters of blood and antibodies to β-endorphin, bradykinin, histamine, dopamine, and serotonin, traditionally used in diagnostic practice, were compared. Deviations of 38–65% in the content of antibodies to dopamine and serotonin were found for patients of the first and second groups compared with the control. A correlation of immunological parameters with biochemical and hematological parameters was found. A direct relationship was found for the level of antibodies to dopamine and AST activity (r = 0.4, p < 0.05), to histamine and ESR concentration (r = 0.6, p < 0.05). Thus, the practical significance of the combined use of tests for assessing the violation of the immunological and biochemical homeostasis of the body of patients with heart disease has been established. Monitoring of additional immunological indicators to assess the development of the disease increases the degree of prognosis of the severity of the pathology. [ABSTRACT FROM AUTHOR]