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An ERK-dependent molecular switch antagonizes fibrosis and promotes regeneration in spiny mice (Acomys).

Authors :
Tomasso, Antonio
Koopmans, Tim
Lijnzaad, Philip
Bartscherer, Kerstin
Seifert, Ashley W.
Source :
Science Advances. 4/28/2023, Vol. 9 Issue 17, p1-21. 21p.
Publication Year :
2023

Abstract

The article discusses the cellular and molecular mechanisms underlying tissue regeneration and fibrotic healing in mammals. Topics discussed include egenerative response of spiny mice (Acomys species), which can naturally regenerate complex tissues, to laboratory mouse strains (Mus), which heal with scar tissue, and ERK activation in nonregenerative species.

Subjects

Subjects :
*SKIN regeneration
*MOLECULAR biology
*CARDIAC regeneration
*REGENERATION (Biology)
*WOUND healing
*MOLECULAR switches
*FIBROBLAST growth factors
*CHONDROITIN sulfate proteoglycan
KERATINOCYTE differentiation

Details

Language :
English
ISSN :
23752548
Volume :
9
Issue :
17
Database :
Academic Search Index
Journal :
Science Advances
Publication Type :
Academic Journal
Accession number :
163358416
Full Text :
https://doi.org/10.1126/sciadv.adf2331
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