Secoiridoids from the traditional Chinese medicine Swertia pseudochinensis.

Detailed phytochemical investigation on the traditional Chinese medicine Swertia pseudochinensis Hara led to the isolation of ten undescribed secoiridoids and fifteen known analogs. Their structures were elucidated by extensive spectroscopic analysis (including 1D and 2D NMR, and HRESIMS). Selected isolates were assayed for their anti-inflammatory and antibacterial activities, and moderate anti-inflammatory activity via inhibiting the secretion of cytokines IL-6 and TNF-α in macrophages RAW264.7 induced by LPS were observed. Antibacterial activity against Staphylococcus aureus was not found at 100 μM. Ten undescribed secoiridoids and fifteen known analogs were isolated from Swertia pseudochinensis. Moderate anti-inflammatory activity was observed for these isolates. [Display omitted] • 25 secoirdoids were isolated from the medicinal plant Swertia pseudochinensis. • 10 undescribed secoirdoids were firstly discovered in this study. • Anti-inflammatory activity was observed for these secoirdoids. [ABSTRACT FROM AUTHOR]