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Structural analysis and properties of two novel pharmaceutical salts of letermovir.
- Source :
-
Journal of Molecular Structure . Jul2023, Vol. 1284, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- • Two novel pharmaceutical salts of letermovir (LM) were successfully achieved. • This is the first report of a single crystal structure of LM, which could contribute to the development of corresponding drugs. • Salt 1 and salt 2 showed better solubility and stability under wet conditions, and had the potential to replace the bulk drug. Two novel pharmaceutical salts of letermovir (LM) were successfully achieved by a slow reaction in solution containing LM with ethylenediamine (EDA) and diisopropylamine (DIPA). In this article, crystal structure, X-ray diffraction, thermal properties, 1H NMR, 13C NMR, HPLC analysis, stability and solubility of salt 1 and salt 2 have been discussed. Salt 1 crystalized in R 3 space group and salt 2 crystalized in P 3 2 21 space group. The formation of salt was proved by p K a rule and single crystal determination. From the perspective of crystal structure, for salt 1 and salt 2 , the strong hydrogen bond makes the crystal structure more stable. The weak interaction between molecules is further studied by Hirshfeld surface and 2D-fingerprint plots. Notably, this is the first report of a single crystal structure of LM, which could contribute to the development of corresponding drugs. In addition, salt 1 and salt 2 showed better solubility and stability under wet conditions, and had the potential to replace the bulk drug. Two novel pharmaceutical salts of letermovir (LM) were successfully synthesized. [Display omitted] [ABSTRACT FROM AUTHOR]
- Subjects :
- *SPACE groups
*CRYSTAL structure
*SINGLE crystals
*SALTS
*DRUG development
Subjects
Details
- Language :
- English
- ISSN :
- 00222860
- Volume :
- 1284
- Database :
- Academic Search Index
- Journal :
- Journal of Molecular Structure
- Publication Type :
- Academic Journal
- Accession number :
- 163338317
- Full Text :
- https://doi.org/10.1016/j.molstruc.2023.135414