A three-dimensional terbium metal − organic framework fluorescent sensor for efficient detection of chloroquine phosphate in serum.

[Display omitted] • Tb-MOF as a potential sensing material for chloroquine phosphate recovered for multiple cycles. • The quenching mechanisms between Tb-MOF and chloroquine phosphate from many aspects investigated. • The sensor used for the visual detection of chloroquine phosphate in serum. A novel three-dimensional (3D) anionic anhydrous metal − organic framework (MOF), {[NH 2 (CH 3) 2 ]·[Tb(pdca) 2 ]} n (Tb-MOF ; H 2 pdca = 2,5-pyridinedicarboxylic acid) has been triumphantly fabricated and structurally characterized. The obtained Tb-MOF displays good stability in some common solvent systems and high temperature environments. The luminescence properties of Tb-MOF are investigated by fluorescence spectra, and the results exhibit superb characteristic emission of Tb3+ ions, which lay a foundation for exploring the fluorescence sensing application of the material. More importantly, based on competitive absorption and dynamic quenching, Tb-MOF can be applied to detect chloroquine phosphate (CQ) used for the treatment of COVID-19 and malaria, showing high sensitivity and fast response speed in the sensing process. Notably, the specific quenching effect between Tb-MOF and CQ in the serum system without interference from other components, demonstrating the practical application potential of Tb-MOF. [ABSTRACT FROM AUTHOR]