Outcomes after liver transplantation in MPV17 deficiency: A rebuttal.

Keywords: MPV17; navajo neurohepatopathy; neurologic outcomes; pediatric liver transplant EN MPV17 navajo neurohepatopathy neurologic outcomes pediatric liver transplant 1 2 2 04/20/23 20230501 NES 230501 We respond with respect to our colleagues Holve and Hu[1] and their decades long experience caring for children on the Navajo Nation. I When faced with a child with MPV17 deficiency in liver failure who faces imminent death without transplantation, our approach has been to offer transplant with direct counseling to families: that liver transplantation does not prevent phenotypically variable neurologic manifestations i . The authors primary concern focuses on long-term neurologic outcomes for four children with MPV17 deficiency (MPV17-related mitochondrial DNA maintenance defect) following liver transplantation. [Extracted from the article]