Germline-encoded amino acid—binding motifs drive immunodominant public antibody responses.

The article discusses that recurrent antibody responses are driven by germline-encoded amino acid–binding (GRAB) motifs, a germline-encoded component of the architecture of the antibody repertoire that predisposes antibodies to recognize particular structures and influences epitope selection and composition. Public epitopes are best aligned for recognition by GRAB motifs and can be bound by a relatively large precursor pool of B cells.